Unveiling the expanding protein universe of life

Drost, H-G

doi:10.1038/s41576-024-00716-y

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Unveiling the expanding protein universe of life

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Drost, H-G
Computational Biology Group, Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Drost, H.-G. (2024). Unveiling the expanding protein universe of life. Nature Reviews Genetics, 25(5), 306. doi:10.1038/s41576-024-00716-y.

Cite as: https://hdl.handle.net/21.11116/0000-000E-8103-C

Abstract

With the cost of DNA sequencing decreasing, we are entering a new era of ‘biosphere genomics’, in which extant and ancient DNA can be captured at planetary scale (that is, earth’s genetics). A recent study in Nature by Pavlopoulos et al. illustrates the incredible sequence diversity that can be unlocked when organizing proteins across this catalogue of life through massively parallel graph-based clustering.