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Journal Article

Cyanation of Tertiary Alkyl Chlorides: A Novel Method for the Geminal Dialkylation of Ketones

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Citation

Reetz, M. T., & Chatziiosifidis, I. (1981). Cyanation of Tertiary Alkyl Chlorides: A Novel Method for the Geminal Dialkylation of Ketones. Angewandte Chemie, International Edition in English, 20(12), 1017-1018. doi:10.1002/anie.198110172.


Cite as: https://hdl.handle.net/21.11116/0000-000E-A3D1-D
Abstract
The SnCl4-catalyzed CC-Coupling of tertiary alkyl halides (1) with trimethyl-silyl cyanide (2) is of preparative interest; the resulting nitriles (3) can be modified in a number of ways, e.g. by Grignard reaction or reduction. Since the educts (1) are accessible from ketones, the geminal dialkylation of ketones is thus possible.