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Highly Nonlinear Dynamics of In Vivo Deep-Tissue Interaction with Femtosecond Laser Pulses at 1030 nm

MPS-Authors
/persons/resource/persons296797

Jun,  Soyeon
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons286182

Herbst,  Andreas
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons286186

Scheffter,  Kilian
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons268904

John,  Nora
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons255612

Kolb,  Julia
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons255618

Wehner,  Daniel
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons61039

Fattahi,  Hanieh
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

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arXiv-2308.05453.pdf
(Preprint), 7MB

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Citation

Jun, S., Herbst, A., Scheffter, K., John, N., Kolb, J., Wehner, D., et al. (2023). Highly Nonlinear Dynamics of In Vivo Deep-Tissue Interaction with Femtosecond Laser Pulses at 1030 nm. arXiv 2308.05453.


Cite as: https://hdl.handle.net/21.11116/0000-000E-A471-9
Abstract
We report on the highly nonlinear behavior observed in the central nervous system tissue of zebrafish (Danio rerio) when exposed to femtosecond pulses at 1030 nm. At this irradiation wavelength, photo damage becomes detectable only after exceeding a specific peak intensity threshold, which is independent of the photon flux and irradiation time, distinguishing it from irradiation at shorter wavelengths. Furthermore, we investigate and quantify the role of excessive heat in reducing the damage threshold, particularly during high-repetition-rate operations, which are desirable for label-free and multi-dimensional microscopy techniques. To verify our findings, we examined cellular responses to tissue damage, including apoptosis and the recruitment of macrophages and fibroblasts at different time points post-irradiation. These findings substantially contribute to advancing the emerging nonlinear optical microscopy techniques and provide a strategy for inducing deep-tissue, precise and localized injuries using near-infrared femtosecond laser pulses.