Penicillin-binding proteins of filaments of Escherichia coli induced by low 
concentrations of nalidixic acid, oxolinic acid, novobiocin or nitrofurantoin

Amaral, L; Schwarz, U; Lorian, V

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Penicillin-binding proteins of filaments of Escherichia coli induced by low concentrations of nalidixic acid, oxolinic acid, novobiocin or nitrofurantoin

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Schwarz, U
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Amaral, L., Schwarz, U., & Lorian, V. (1986). Penicillin-binding proteins of filaments of Escherichia coli induced by low concentrations of nalidixic acid, oxolinic acid, novobiocin or nitrofurantoin. Drugs under Experimental and Clinical Research, 12(8), 653-656.

Cite as: https://hdl.handle.net/21.11116/0000-000E-A4BF-2

Abstract

Nalidixic acid, novobiocin, oxolinic acid and nitrofurantoin, each at low concentrations, cause filamentation of Gram-negative bacilli. Filamentation induced by beta-lactam antibiotics has been correlated to the binding of these antibiotics to specific penicillin-binding proteins (PBPs) of the envelope of Gram-negative bacilli. The studies reported herein indicate that the former group of non-beta-lactam antibiotics do not bind to any of the PBPs of Escherichia coli. However, PBP 1a, PBP 4 and PBP 5/6 of the filaments induced by these agents are increased significantly.