Inhibition of an Autolysin Together with PBP3 Causes the Formation of Bulges: 
Identification of the Soluble Lytic Tranglycosylase in E. coli as the Specific 
Target of Bulgecin

Templin, MF; Edwards, DH; Höltje, J-V

doi:10.1007/978-1-4757-9359-8_28

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Inhibition of an Autolysin Together with PBP3 Causes the Formation of Bulges: Identification of the Soluble Lytic Tranglycosylase in E. coli as the Specific Target of Bulgecin

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Templin, MF
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Höltje, J-V
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Templin, M., Edwards, D., & Höltje, J.-V. (1993). Inhibition of an Autolysin Together with PBP3 Causes the Formation of Bulges: Identification of the Soluble Lytic Tranglycosylase in E. coli as the Specific Target of Bulgecin. In M. Pedro, J.-V. Höltje, & W. Löffelhardt (Eds.), Bacterial Growth and Lysis: Metabolism and Structure of the Bacterial Sacculus (pp. 241-244). Boston, MA, USA: Springer.

Cite as: https://hdl.handle.net/21.11116/0000-000E-A4E6-5

Abstract

A coordinated action of murein synthetases and murein hydrolases is assumed to be essential for proper growth of the bacterial cell. A disturbance of this balance, for example by blocking parts of the synthetic pathway turns the hydrolases into autolysins which then cause lysis of the cell (Tomasz, 1979).