Variational inference accelerates accurate DNA mixture deconvolution.

Susik, Mateusz; Sbalzarini, Ivo F.

doi:10.1016/j.fsigen.2023.102890

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Variational inference accelerates accurate DNA mixture deconvolution.

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Susik, Mateusz
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Sbalzarini, Ivo F.
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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https://publications.mpi-cbg.de/Susik_2023_8549.pdf
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Citation

Susik, M., & Sbalzarini, I. F. (2023). Variational inference accelerates accurate DNA mixture deconvolution. Forensic science international. Genetics, 65: 102890. doi:10.1016/j.fsigen.2023.102890.

Cite as: https://hdl.handle.net/21.11116/0000-000E-AB68-D

Abstract

We investigate a class of DNA mixture deconvolution algorithms based on variational inference, and we show that this can significantly reduce computational runtimes with little or no effect on the accuracy and precision of the result. In particular, we consider Stein Variational Gradient Descent (SVGD) and Variational Inference (VI) with an evidence lower-bound objective. Both provide alternatives to the commonly used Markov-Chain Monte-Carlo methods for estimating the model posterior in Bayesian probabilistic genotyping. We demonstrate that both SVGD and VI significantly reduce computational costs over the current state of the art. Importantly, VI does so without sacrificing precision or accuracy, presenting an overall improvement over previously published methods.