CLAUDIO: Automated structural analysis of cross-linking data

Röhl, A; Netz, E; Kohlbacher, O; Elhabashy, H

doi:10.1093/bioinformatics/btae146

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CLAUDIO: Automated structural analysis of cross-linking data

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Elhabashy, H
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Röhl, A., Netz, E., Kohlbacher, O., & Elhabashy, H. (2024). CLAUDIO: Automated structural analysis of cross-linking data. Bioinformatics, 40(4): btae146. doi:10.1093/bioinformatics/btae146.

Cite as: https://hdl.handle.net/21.11116/0000-000F-1E9D-0

Abstract

Motivation: Cross-linking mass spectrometry has made remarkable advancements in the high-throughput characterization of protein structures and interactions. The resulting pairs of cross-linked peptides typically require geometric assessment and validation, given the availability of their corresponding structures.
Results: CLAUDIO is an open-source software tool designed for the automated analysis and validation of different varieties of large-scale cross-linking experiments. Many of the otherwise manual processes for structural validation (i.e. structure retrieval and mapping) are performed fully automatically to simplify and accelerate the data interpretation process. Additionally, CLAUDIO has the ability to remap intra-protein links as inter-protein links and discover evidence for homo-multimers.
Availability: CLAUDIO is available as open-source software under the MIT license at https://github.com/KohlbacherLab/CLAUDIO.