Enhancer contacts during embryonic development show diverse interaction modes 
and modest yet significant increases upon gene activation

Ibrahim, Daniel M.

doi:10.1038/s41588-024-01700-2

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学術論文

Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation

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Ibrahim, Daniel M.
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

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引用

Ibrahim, D. M. (2024). Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation. Nature Genetics. doi:10.1038/s41588-024-01700-2.

引用: https://hdl.handle.net/21.11116/0000-000F-22EF-E

要旨

The exact relationship between 3D chromatin interactions and enhancer function is unclear. By probing three-dimensional enhancer interactions in developing embryos, two studies now show nuanced dynamics in tissue-specific contexts and reveal how moderately increased enhancer–promoter interactions coincide with functionality.