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Poster

SABRE Hyperpolarization Ultralow-field MRI Platform

MPS-Authors
/persons/resource/persons252801

Kempf,  N       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons297574

Neumann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons286711

Bullinger,  F
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler,  K       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133443

Buckenmaier,  K       
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://www.enc-conference.org/resources/Documents/General/ENC%202024%20Final%20Program%20w-Laukien%20winner_as%20of%204-9-2024.pdf
(Abstract)

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Citation

Kempf, N., Pravdivtsev, A., Plaumann, M., Körber, R., Engelmann, J., Neumann, R., et al. (2024). SABRE Hyperpolarization Ultralow-field MRI Platform. Poster presented at 65th Experimental Nuclear Magnetic Resonance Conference (ENC 2024), Pacific Grove, CA, USA.


Cite as: https://hdl.handle.net/21.11116/0000-000F-232A-B
Abstract
The zero and ultra-low field regime opens up new opportunities for NMR by parahydrogen-based hyperpolarization. Our in situ combination of SABRE with a SQUID between 10 fT and 30 mT embodies a highly versatile magnetic resonance system. Recent efforts have improved 15N polarization by 30 % with alt-SABRE- SHEATH and polarized [1-13C]pyruvate in situ with LIGHT-SABRE continuously without magnetic field cycling. We obtained 3- dimensional 13C images of [1-13C]pyruvate in a phantom with sub- millimeter resolution at 120 μT. Using a SABRE-SHEATH ZULF sequence we measured the hyperpolarized signals of [1-13C]pyruvate between 1 nT and 100 μT, showing the transition between the Zeeman dominated and the J-coupling dominated regime. The results pave the way for in vivo ULF imaging with SABRE.