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Meeting Abstract

Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multi-parametric mapping (MPM)

MPS-Authors
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Seif,  Maryam
Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Leutritz,  Tobias       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Freund,  Patrick
Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Wellcome Trust Centre for Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom;

External Resource

https://www.ismrm.org/23/program-files/D-123.htm
(Abstract)

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Citation

Schading, S., Seif, M., Leutritz, T., Hupp, M., Curt, A., Weiskopf, N., et al. (2023). Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multi-parametric mapping (MPM). In Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition.


Cite as: https://hdl.handle.net/21.11116/0000-000F-3306-1
Abstract
MRI acquisition time is a main factor for patient's comfort and motion artifacts. To avoid additional time consuming T1-w MPRAGE imaging for measuring spinal cord atrophy, when quantitative multi-parameter maps (MPM) are available, we reconstructed and validated a synthetic T1-w (synT1-w) based on MPMs. Test-retest repeatability was assessed and synT 1-w images were compared with T1-w MPRAGE in a longitudinal study following spinal cord injury. Measures derived from synT1-w demonstrated high intra- and inter-site repeatability with only small difference when compared to MPRAGE. The estimated effects of spinal cord atrophy agreed with those obtained from MPRAGE.