(Alternative) transcription start sites as regulators of RNA processing

Alfonso-Gonzalez, Carlos; Hilgers, Valérie

doi:10.1016/j.tcb.2024.02.010

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(Alternative) transcription start sites as regulators of RNA processing

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Alfonso-Gonzalez, Carlos
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Hilgers, Valérie
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Alfonso-Gonzalez, C., & Hilgers, V. (2024). (Alternative) transcription start sites as regulators of RNA processing. Trends in Cell Biology, 34, 1018-1028. doi:10.1016/j.tcb.2024.02.010.

Cite as: https://hdl.handle.net/21.11116/0000-000F-3705-E

Abstract

Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that enables genes to choose between multiple genomic loci for initiating transcription. This mechanism is tightly controlled during development and is often altered in disease states. In this review, we examine the growing evidence highlighting a role for transcription start sites (TSSs) in the regulation of mRNA isoform selection during and after transcription. We discuss how the choice of transcription initiation sites influences RNA processing and the importance of this crosstalk for cell identity and organism function. We also speculate on possible mechanisms underlying the integration of transcriptional and post-transcriptional processes.