Nonsense-mediated mRNA decay: Target genes and functional diversification of 
effectors

Rehwinkel, J; Raes, J; Izaurralde, E

doi:10.1016/j.tibs.2006.09.005

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors

MPS-Authors

/persons/resource/persons271767

Izaurralde, E
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Rehwinkel, J., Raes, J., & Izaurralde, E. (2006). Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends in biochemical sciences, 31(11), 639-646. doi:10.1016/j.tibs.2006.09.005.

Cite as: https://hdl.handle.net/21.11116/0000-000F-3A5E-8

Abstract

Recent genome-wide identification of nonsense-mediated mRNA decay (NMD) targets in yeast, fruitfly and human cells has provided insight into the biological functions and evolution of this mRNA quality control mechanism, revealing that NMD post-transcriptionally regulates an important fraction of the transcriptome. NMD targets are associated with a broad range of biological processes, but most of these targets are not encoded by orthologous genes across different species. Yeast and fruitfly NMD effectors regulate common targets in concert, but parallel pathways have evolved in humans, whereby NMD effectors have acquired additional functions. Thus, the phenotypic differences observed across species after inhibition of NMD are driven not only by the functional diversification of NMD effectors but also by changes in the repertoire of regulated genes.