MOMP in the absence of BH3-only proteins

García-Sáez, Ana J.; Villunger, Andreas

doi:10.1101/gad.281519.116

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MOMP in the absence of BH3-only proteins

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García-Sáez, A. J., & Villunger, A. (2016). MOMP in the absence of BH3-only proteins. Genes and Development, 30(8), 878-880. doi:10.1101/gad.281519.116.

Cite as: https://hdl.handle.net/21.11116/0000-000F-3BF6-A

Abstract

The minimum requirement for mitochondrial apoptosis has been controversial ever since the discovery of BCL-2 as a cell death regulator. In this issue ofGenes&Development, O'Neill and colleagues (pp. 973-988) end a long-standing debate by creating a cellular system free of BCL-2 family proteins, thereby identifying the outer mitochondrial membrane rather than BH3-only proteins as the only requirement for BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP).