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Journal Article

Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish

MPS-Authors
/persons/resource/persons296797

Jun,  Soyeon
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons286182

Herbst,  Andreas
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons286186

Scheffter,  Kilian
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

/persons/resource/persons268904

John,  Nora
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons255612

Kolb,  Julia
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons255618

Wehner,  Daniel
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

/persons/resource/persons61039

Fattahi,  Hanieh
Fattahi Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander-Universität Erlangen-Nürnberg, External Organizations;

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s42005-024-01653-2.pdf
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Citation

Jun, S., Herbst, A., Scheffter, K., John, N., Kolb, J., Wehner, D., et al. (2024). Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish. Communications Physics, (7): 161. doi:10.1038/s42005-024-01653-2.


Cite as: https://hdl.handle.net/21.11116/0000-000F-4F6C-1
Abstract
Understanding the photodamage mechanism underlying the highly nonlinear dynamic of femtosecond laser pulses at the second transparent window of tissue is crucial for label-free microscopy. Here, we report the identification of two cavitation regimes from 1030 nm pulses when interacting with the central nervous system in zebrafish. We show that at low repetition rates, the damage is confined due to plasma-based ablation and sudden local temperature rise. At high repetition rates, the damage becomes collateral due to plasma-mediated photochemistry. Furthermore, we investigate the role of fluorescence labels with linear and nonlinear absorption pathways in optical breakdown. To verify our findings, we examined cell death and cellular responses to tissue damage, including the recruitment of fibroblasts and immune cells after irradiation. These findings contribute to advancing the emerging nonlinear optical microscopy techniques and provide a strategy for inducing precise, and localized injuries using near-infrared femtosecond laser pulses.