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Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancer

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Staab,  HJ
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Anderer,  FA
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Staab, H., Anderer, F., Stumpf, E., & Fischer, R. (1978). Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancer. The American Journal of Surgery, 136(3), 322-327. doi:10.1016/0002-9610(78)90285-4.


Cite as: https://hdl.handle.net/21.11116/0000-000F-5089-C
Abstract
The postoperative carcinoembryonic antigen (CEA) time courses of patients with histologically proven adenocarcinoma of the gastrointestinal tract were analyzed to establish a possible correlation with distinct types of disease progression. The diagnosis of tumor progression was obtained by second-look surgery, and in some cases by other clinical diagnostic procedures. In thirty-one of thirty-four patients studied, tumor progression correlated with increasing CEA levels. The calculation of the slopes of the CEA increase in the computerized CEA surveillance diagrams represented a parameter that discriminated between local tumor recurrence and widespread tumor dissemination. All localized tumor recurrences exhibited a flat slope in the range of 0.08 to 0.30 ng CEA increase/ml serum within ten days, with a mean value of 0.17 ng/ml in ten days. The CEA slopes in cases of liver metastases were relatively steep and ranged from 0.9 to 3.8 ng/ml in ten days, yielding a mean slope of 2.2 ng CEA increase/ml serum in ten days.