English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Growth of human colonic adenocarcinoma and development of serum CEA in in athymic mice. I: Strict correlation of tumour size and mass with serum CEA concentration during logarithmic growth

MPS-Authors
/persons/resource/persons285242

Staab,  HJ
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons282624

Anderer,  FA
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Staab, H., & Anderer, F. (1982). Growth of human colonic adenocarcinoma and development of serum CEA in in athymic mice. I: Strict correlation of tumour size and mass with serum CEA concentration during logarithmic growth. British Journal of Cancer, 46(6), 841-847. doi:10.1038/bjc.1982.293.


Cite as: https://hdl.handle.net/21.11116/0000-000F-50FF-8
Abstract
The secretion of CEA into the blood of athymic mice was studied with 4 sublines of human colonic adenocarcinoma cell lines, HT 29 and SLu. Growth curves based on tumour volume (caliper measurements) or tumour mass (weight) correlated with a concomitant increase of serum CEA during the logarithmic growth phase, but showed a marked dissociation when the growth rate slowed down. In the logarithmic growth phase doubling times between 2 and 6 days were calculated and about 6-7 doubling times passed until the shift in the growth rate was observed, independently of the sublines transplanted. Constant increases of CEA between 0.03 and 0.45 microgram/l serum per mm3 increase of tumour volume, depending on the sublines, were recorded during the logarithmic growth phase. Sublines releasing high amounts of CEA in vitro (cell culture) retained this characteristic in vivo. Correlation between tumour volume and tumour mass or serum CEA showed correlation coefficients of 0.820-0.977 during the logarithmic growth phase.