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Journal Article

The underappreciated diversity of bile acid modifications

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Turck,  Christoph W.
RG Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Mohanty, I., Mannochio-Russo, H., Schweer, J. V., Abiead, Y. E., Bittremieux, W., Xing, S., et al. (2024). The underappreciated diversity of bile acid modifications. CELL, 187(7), 1801-1818. doi:10.1016/j.cell.2024.02.019.


Cite as: https://hdl.handle.net/21.11116/0000-000F-51B1-D
Abstract
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource of tandem mass spectrometry (MS/MS) spectra by filtering 1.2 billion publicly available MS/MS spectra for bileacid -selective ion patterns. Thousands of modifications are distributed throughout animal and human bodies as well as microbial cultures. We employed this MS/MS library to identify polyamine bile amidates, prevalent in carnivores. They are present in humans, and their levels alter with a diet change from a Mediterranean to a typical American diet. This work highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover metabolites. The availability of a modification -centric bile acid MS/MS library will inform future studies investigating bile acid roles in health and disease.