Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

Brose, Nils; Petrenko, Alexander G.; Südhof, Thomas C.; Jahn, Reinhard

doi:10.1126/science.1589771

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Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

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Brose, Nils
Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Citation

Brose, N., Petrenko, A. G., Südhof, T. C., & Jahn, R. (1992). Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface. Science, 256(5059), 1021-1025. doi:10.1126/science.1589771.

Cite as: https://hdl.handle.net/21.11116/0000-000F-5A66-A

Abstract

Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing the calcium signal into membrane fusion are still an enigma. It is reported here that synaptotagmin, a highly conserved synaptic vesicle protein, binds calcium at physiological concentrations in a complex with negatively charged phospholipids. This binding is specific for calcium and involves the cytoplasmic domain of synaptotagmin. Calcium binding is dependent on the intact oligomeric structure of synaptotagmin (it is abolished by proteclytic cleavage at a single site). These results suggest that synaptotagmin acts as a cooperative calcium receptor in exocytosis.