Coordinating mitochondrial translation with assembly of the OXPHOS complexes

Kremer, L. S.; Rehling, Peter

doi:10.1093/hmg/ddae025

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Coordinating mitochondrial translation with assembly of the OXPHOS complexes

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Rehling, Peter
MPI-NAT Fellow Mitochondrial Biogenesis and Assembly of membrane Protein Complexes, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Kremer, L. S., & Rehling, P. (2024). Coordinating mitochondrial translation with assembly of the OXPHOS complexes. Human Molecular Genetics, 33(R1), R47-R52. doi:10.1093/hmg/ddae025.

Cite as: https://hdl.handle.net/21.11116/0000-000F-663B-D

Abstract

The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are encoded by the nuclear DNA and imported into mitochondria, while a small subset is encoded on the mitochondrion’s own genome, the mitochondrial DNA (mtDNA). The nuclear and mtDNA encoded subunits must be expressed and assembled in a highly orchestrated fashion to form a functional OXPHOS system and meanwhile prevent the generation of any harmful assembly intermediates. While several mechanisms have evolved in eukaryotes to achieve such a coordinated expression, this review will focus on how the translation of mtDNA encoded OXPHOS subunits is tailored to OXPHOS assembly.