English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Monoclonal antibody-defined circulating human tumor-associated antigen with epitope shared by cytokeratins

MPS-Authors
/persons/resource/persons201664

Hollmann,  M       
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons285242

Staab,  HJ
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons284865

Spindler,  E
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons284863

Sproll,  M
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons282624

Anderer,  FA
Anderer Group, Friedrich Miescher Laboratory, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Hollmann, M., Staab, H., Spindler, E., Sproll, M., Anderer, F., & Fortmeyer, H. (1985). Monoclonal antibody-defined circulating human tumor-associated antigen with epitope shared by cytokeratins. Biochemical and Biophysical Research Communications, 128(1), 34-39. doi:10.1016/0006-291x(85)91640-7.


Cite as: https://hdl.handle.net/21.11116/0000-000F-60BB-2
Abstract
Sera of human colonic carcinoma xenografted rnu/nu rats were used to immunize rnu/+rats in order to obtain an immune response against circulating human tumor-associated components. After fusion of rat spleen cells with mouse myeloma cells monoclonal antibody MAB 108 could be established which reacted with two 40 and 45 kD cytokeratins as well as with vimentin, with a soluble 37 kD protein apparently derived from the 45 kD protein and with a 37 kD protein released by tumor cells. The MAB 108-specific epitope was also detected in tissue polypeptide antigen (TPA), a human tumor-associated antigen originally described by Björklund et al. (22).