Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Molecular surface chemistry defines nematode development, identity and behaviour

MPG-Autoren
/persons/resource/persons290325

Hiramatsu,  Fumie       
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;
International Max Planck Research School (IMPRS) for Brain and Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

/persons/resource/persons252140

Lightfoot,  James W       
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

Externe Ressourcen

https://www.biorxiv.org/content/10.1101/2024.04.24.590549v1
(Preprint)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Kotowska, A. M., Hiramatsu, F., Alexander, M. R., Scurr, D. J., Lightfoot, J. W., & Chauhan, V. M. (2024). Molecular surface chemistry defines nematode development, identity and behaviour. bioRxiv. doi:10.1101/2024.04.24.590549.


Zitierlink: https://hdl.handle.net/21.11116/0000-000F-639D-1
Zusammenfassung
Chemical signalling facilitates organismal communication and coordinates physiological and behavioural processes. In nematodes, chemical signalling has focused on secreted molecules leaving the surface’s communicative potential unexplored. Utilising 3D-OrbiSIMS surface-sensitive mass spectrometry, we directly characterise the molecular surface composition of Caenorhabditis elegans and Pristionchus pacificus. Their surfaces consist of a complex, lipid-dominated landscape with distinct developmental profiles and species-specific characteristics. These surface-anchored chemistries depend on the peroxisomal fatty acid β-oxidation component daf-22 and are essential for interaction-based behaviours including predation and kin-recognition. Specific lipid molecules identified as putative kin-recognition associated surface components include diglyceride (DG O-50:13), ceramide phosphate (CerP 41:1;O3), and hexosylceramide (HexCer 40:2;O3). Thus, we reveal the nematode surface is a dynamic signalling interface, pivotal for deciphering molecular mechanisms regulating development, identity and contact-dependent behaviour.