Implantable photonic neural probes with out-of-plane focusing grating emitters

Xue, Tianyuan; Stalmashonak, Andrei; Chen, Fu-Der; Ding, Peisheng; Luo, Xianshu; Chua, Hongyao; Lo, Guo-Qiang; Sacher, Wesley D.; Poon, Joyce K. S.

doi:10.1038/s41598-024-64037-0

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Implantable photonic neural probes with out-of-plane focusing grating emitters

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Xue, Tianyuan
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

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Stalmashonak, Andrei
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons260636

Chen, Fu-Der
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons291494

Ding, Peisheng
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons258003

Sacher, Wesley D.
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons257612

Poon, Joyce K. S.
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

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Citation

Xue, T., Stalmashonak, A., Chen, F.-D., Ding, P., Luo, X., Chua, H., et al. (2024). Implantable photonic neural probes with out-of-plane focusing grating emitters. Scientific Reports, 14: 13812. doi:10.1038/s41598-024-64037-0.

Cite as: https://hdl.handle.net/21.11116/0000-000F-760B-1

Abstract

We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.