Tracking gene order provides a new perspective on intraspecific evolution in 
microbiotas

Enav, H; Ley, R

doi:10.1038/s41587-024-02277-1

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Tracking gene order provides a new perspective on intraspecific evolution in microbiotas

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Enav, H
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Ley, R
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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https://www.nature.com/articles/s41587-024-02277-1.pdf
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Citation

Enav, H., & Ley, R. (2024). Tracking gene order provides a new perspective on intraspecific evolution in microbiotas. Nature Biotechnology, Epub ahead. doi:10.1038/s41587-024-02277-1.

Cite as: https://hdl.handle.net/21.11116/0000-000F-76D3-E

Abstract

We developed SynTracker, a tool to track conspecific microbial strains using genome synteny. SynTracker is sensitive to genomic structural variation but not to single-nucleotide polymorphisms (SNPs). Combining SynTracker with methods for tracking strains using SNP profiles, we were able to detect species evolving by accumulating predominantly SNPs or predominantly structural variants.