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Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography

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Schneider,  Jonathan
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Schneider, J., & Jasnin, M. (2024). Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography. Current Opinion in Cell Biology, 88: 102356. doi:10.1016/j.ceb.2024.102356.


Cite as: https://hdl.handle.net/21.11116/0000-000F-77AA-C
Abstract
Cryo-electron tomography (cryo-ET) has begun to provide intricate views of cellular architecture at unprecedented resolutions. Considerable efforts are being made to further optimize and automate the cryo-ET workflow, from sample preparation to data acquisition and analysis, to enable visual proteomics inside of cells. Here, we will discuss the latest advances in cryo-ET that go hand in hand with their application to the actin cytoskeleton. The development of deep learning tools for automated annotation of tomographic reconstructions and the serial lift -out sample preparation procedure will soon make it possible to perform high -resolution structural biology in a whole new range of samples, from multicellular organisms to organoids and tissues.