English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Editorial

Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

MPS-Authors
/persons/resource/persons197309

Outeiro,  Tiago Fleming
Guest Group Experimental Neurodegeneration, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Publisher Version
(Publisher version), 322KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Outeiro, T. F., Brocardo, P. S., & Gelain, D. P. (2024). Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions. Journal of Neurochemistry, 168(8), 1421-1683. doi:10.1111/jnc.16163.


Cite as: https://hdl.handle.net/21.11116/0000-000F-7C9F-4
Abstract
Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network. The specific molecular drivers of protein aggregation in certain cell types are not well understood, posing tremendous challenges to current research aimed at devising strategies to treat neurodegenerative diseases. This preface introduces the special issue “Aging and Neurodegeneration: from molecular mechanisms to therapeutic interventions,” featuring articles that assess the drivers of pathology in the aging cell, including oxidative stress, protein glycation/aggregation, and mitochondrial impairment.