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Journal Article

Complex stiffness gradient substrates for studying mechanotactic cell migration

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Citation

Kuo, C.-H.-R., Xian, J., Brenton, J. D., Franze, K., & Sivaniah, E. (2012). Complex stiffness gradient substrates for studying mechanotactic cell migration. Advanced Materials (Deerfield Beach, Fla.), 24(45), 6059-6064. doi:10.1002/adma.201202520.


Cite as: https://hdl.handle.net/21.11116/0000-000F-8A4B-2
Abstract
Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm.