Potential thresholds of critically increased cardiac-related spinal cord motion 
in degenerative cervical myelopathy

Pfender, Nikolai; Jutzeler, Catherine R.; Hubli, Michèle; Scheuren, Paulina S.; Pfyffer, Dario; Zipser, Carl M.; Rosner, Jan; Friedl, Susanne; Sutter, Reto; Spirig, José M.; Betz, Michael; Schubert, Martin; Seif, Maryam; Freund, Patrick; Farshad, Mazda; Curt, Armin; Hupp, Markus

doi:10.3389/fneur.2024.1411182

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Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy

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Seif, Maryam
Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Freund, Patrick
Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Pfender, N., Jutzeler, C. R., Hubli, M., Scheuren, P. S., Pfyffer, D., Zipser, C. M., et al. (2024). Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy. Frontiers in Neurology, 15: 1411182. doi:10.3389/fneur.2024.1411182.

Cite as: https://hdl.handle.net/21.11116/0000-000F-8913-1

Abstract

Introduction: New diagnostic techniques are a substantial research focus in degenerative cervical myelopathy (DCM). This cross-sectional study determined the significance of cardiac-related spinal cord motion and the extent of spinal stenosis as indicators of mechanical strain on the cord.

Methods: Eighty-four DCM patients underwent MRI/clinical assessments and were classified as MRI+ [T2-weighted (T2w) hyperintense lesion in MRI] or MRI- (no T2w-hyperintense lesion). Cord motion (displacement assessed by phase-contrast MRI) and spinal stenosis [adapted spinal canal occupation ratio (aSCOR)] were related to neurological (sensory/motor) and neurophysiological readouts [contact heat evoked potentials (CHEPs)] by receiver operating characteristic (ROC) analysis.

Results: MRI+ patients (N = 31; 36.9%) were more impaired compared to MRI- patients (N = 53; 63.1%) based on the modified Japanese Orthopedic Association (mJOA) subscores for upper {MRI+ [median (Interquartile range)]: 4 (4-5); MRI-: 5 (5-5); p < 0.01} and lower extremity [MRI+: 6 (6-7); MRI-: 7 (6-7); p = 0.03] motor dysfunction and the monofilament score [MRI+: 21 (18-23); MRI-: 24 (22-24); p < 0.01]. Both patient groups showed similar extent of cord motion and stenosis. Only in the MRI- group displacement identified patients with pathologic assessments [trunk/lower extremity pin prick score (T/LEPP): AUC = 0.67, p = 0.03; CHEPs: AUC = 0.73, p = 0.01]. Cord motion thresholds: T/LEPP: 1.67 mm (sensitivity 84.6%, specificity 52.5%); CHEPs: 1.96 mm (sensitivity 83.3%, specificity 65.6%). The aSCOR failed to show any relation to the clinical assessments.

Discussion: These findings affirm cord motion measurements as a promising additional biomarker to improve the clinical workup and to enable timely surgical treatment particularly in MRI- DCM patients.