Laser-induced switching of the biological activity of phosphonate molecules

Kolesnikov, Ilya; Khokhlova, Anastasia; Pankin, Dmitry; Pilip, Anna; Egorova, Anastasia; Zigel, Vladislav; Gureev, Maxim; Leuchs, Gerd; Manshina, Alina

doi:10.1039/d1nj02487f

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Laser-induced switching of the biological activity of phosphonate molecules

MPS-Authors

/persons/resource/persons201115

Leuchs, Gerd
Leuchs Emeritus Group, Emeritus Groups, Max Planck Institute for the Science of Light, Max Planck Society;

External Resource

https://pubs.rsc.org/en/content/articlelanding/2021/nj/d1nj02487f
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Kolesnikov, I., Khokhlova, A., Pankin, D., Pilip, A., Egorova, A., Zigel, V., et al. (2021). Laser-induced switching of the biological activity of phosphonate molecules. NEW JOURNAL OF CHEMISTRY, 45(34), 15195-15199. doi:10.1039/d1nj02487f.

Cite as: https://hdl.handle.net/21.11116/0000-000F-8E12-D

Abstract

Butyrylcholinesterase inhibition and its enhancement as a result of laser irradiation are demonstrated for the first time for a series of phosphorylated arylaminomalonates. The effect of substituents in the phenyl group on butyrylcholinesterase inhibition and its laser-activated enhancement is revealed experimentally and confirmed by molecular dynamics and docking modelling.