Continuous flow oxidation of alkynes with KMnO4 for the synthesis of 
1,2-diketone derivatives

Velichko, Viktoria; Cambié, Dario; Secci, Francesco

doi:10.1039/D3RE00716B

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Continuous flow oxidation of alkynes with KMnO₄ for the synthesis of 1,2-diketone derivatives

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Velichko, Viktoria
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Cambié, Dario
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Velichko, V., Cambié, D., & Secci, F. (2024). Continuous flow oxidation of alkynes with KMnO₄ for the synthesis of 1,2-diketone derivatives. Reaction chemistry & engineering, 9(7), 1721-1725. doi:10.1039/D3RE00716B.

Cite as: https://hdl.handle.net/21.11116/0000-000F-9751-B

Abstract

A continuous-flow process for the conversion of functionalized alkynes to 1,2-diketones and α-keto-carboxylic acids, using KMnO₄ as the oxidizing agent has been developed. The simultaneous use of pulsed sonication combined with an in-line liquid–liquid separation process, avoids clogging of the microfluidic reactor by MnO₂ slurries, ensuring reproducibility and high yields.