English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Efficient termination of cardiac arrhythmias using optogenetic resonant feedback pacing

MPS-Authors
/persons/resource/persons256617

Hussaini,  Sayedeh
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons297925

Mamyraiym Kyzy,  Aidai       
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173650

Schröder-Schetelig,  Johannes
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons300364

Lädke,  Sarah Louisa
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons256620

Venkatesan,  Vishalini
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons227679

Diaz-Maue,  Laura
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons300368

Quiñonez Uribe,  Raul Alejandro
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons188803

Richter,  Claudia
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons226975

Majumder,  Rupamanjari
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173574

Krinski,  Valentin
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173583

Luther,  Stefan
Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Publisher Version
(Publisher version), 5MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Hussaini, S., Mamyraiym Kyzy, A., Schröder-Schetelig, J., Lädke, S. L., Venkatesan, V., Diaz-Maue, L., et al. (2024). Efficient termination of cardiac arrhythmias using optogenetic resonant feedback pacing. Chaos: an interdisciplinary journal of nonlinear science, 34: 031103. doi:10.1063/5.0191519.


Cite as: https://hdl.handle.net/21.11116/0000-000F-9D06-A
Abstract
Malignant cardiac tachyarrhythmias are associated with complex spatiotemporal excitation of the heart. The termination of these lifethreatening arrhythmias requires high-energy electrical shocks that have significant side effects, including tissue damage, excruciating pain, and worsening prognosis. This significant medical need has motivated the search for alternative approaches that mitigate the side effects, based on a comprehensive understanding of the nonlinear dynamics of the heart. Cardiac optogenetics enables the manipulation of cellular function using light, enhancing our understanding of nonlinear cardiac function and control. Here, we investigate the efficacy of optically resonant feedback pacing (ORFP) to terminate ventricular tachyarrhythmias using numerical simulations and experiments in transgenic Langendorff perfused mouse hearts. We show that ORFP outperforms the termination efficacy of the optical single-pulse (OSP) approach. When using ORFP, the total energy required for arrhythmia termination, i.e., the energy summed over all pulses in the sequence, is 1 mJ. With a success rate of 50%, the energy per pulse is 40 times lower than with OSP with a pulse duration of 10 ms. We demonstrate that even at light intensities below the excitation threshold, ORFP enables the termination of arrhythmias by spatiotemporal modulation of excitability inducing spiral wave drift.