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Journal Article

Shared vulnerability and sex-dependent polygenic burden in psychotic disorders

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Papiol,  Sergi
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Mitjans, M., Papiol, S., Fatjo-Vilas, M., Gonzalez-Penas, J., Acosta-Diez, M., Zafrilla-Lopez, M., et al. (2024). Shared vulnerability and sex-dependent polygenic burden in psychotic disorders. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 86, 49-54. doi:10.1016/j.euroneuro.2024.04.017.


Cite as: https://hdl.handle.net/21.11116/0000-000F-A09C-C
Abstract
Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sexdependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.