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Actomyosin bundles serve as a tension sensor and a platform for ERK activation

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Zitation

Hirata, H., Gupta, M., Vedula, S. R. K., Lim, C. T., Ladoux, B., & Sokabe, M. (2014). Actomyosin bundles serve as a tension sensor and a platform for ERK activation. EMBO Reports, 16(2), 250-257. doi:10.15252/embr.201439140.


Zitierlink: https://hdl.handle.net/21.11116/0000-000F-B42D-4
Zusammenfassung
Tensile forces generated by stress fibers drive signal transduction events at focal adhesions. Here, we report that stress fibers per se act as a platform for tension-induced activation of biochemical signals. The MAP kinase, ERK is activated on stress fibers in a myosin II-dependent manner. In myosin II-inhibited cells, uniaxial stretching of cell adhesion substrates restores ERK activation on stress fibers. By quantifying myosin II- or mechanical stretch-mediated tensile forces in individual stress fibers, we show that ERK activation on stress fibers correlates positively with tensile forces acting on the fibers, indicating stress fibers as a tension sensor in ERK activation. Myosin II-dependent ERK activation is also observed on actomyosin bundles connecting E-cadherin clusters, thus suggesting that actomyosin bundles, in general, work as a platform for tension-dependent ERK activation.