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The iron nitrogenase reduces carbon dioxide to formate and methane under physiological conditions: A route to feedstock chemicals

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Oehlmann,  Niels N.
Emmy Noether research Group Microbial Metalloenzymes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Schmidt,  Frederik V.
Emmy Noether research Group Microbial Metalloenzymes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Herzog,  Marcello
Emmy Noether research Group Microbial Metalloenzymes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

Goldman,  Annelise L.
external;
Emmy Noether research Group Microbial Metalloenzymes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Rebelein,  Johannes G.       
Emmy Noether research Group Microbial Metalloenzymes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Citation

Oehlmann, N. N., Schmidt, F. V., Herzog, M., Goldman, A. L., & Rebelein, J. G. (2024). The iron nitrogenase reduces carbon dioxide to formate and methane under physiological conditions: A route to feedstock chemicals. Science Advances, 10(33): eado7729. doi:10.1126/sciadv.ado7729.


Cite as: https://hdl.handle.net/21.11116/0000-000F-B653-6
Abstract
Nitrogenases are the only known enzymes that reduce molecular nitrogen (N2) to ammonia. Recent findings have demonstrated that nitrogenases also reduce the greenhouse gas carbon dioxide (CO2), suggesting CO2 to be a competitor of N2. However, the impact of omnipresent CO2 on N2 fixation has not been investigated to date. Here, we study the competing reduction of CO2 and N2 by the two nitrogenases of Rhodobacter capsulatus, the molybdenum and the iron nitrogenase. The iron nitrogenase is almost threefold more efficient in CO2 reduction and profoundly less selective for N2 than the molybdenum isoform under mixtures of N2 and CO2. Correspondingly, the growth rate of diazotrophically grown R. capsulatus strains relying on the iron nitrogenase notably decreased after adding CO2. The in vivo CO2 activity of the iron nitrogenase facilitates the light-driven extracellular accumulation of formate and methane, one-carbon substrates for other microbes, and feedstock chemicals for a circular economy. Iron nitrogenases produce the feedstock chemical formate from environmental CO2 and offer opportunities for a green economy.