Importin 13: Eine Rundreise durch die Kernpore [Importin 13: a round trip 
through the nuclear pore]

Bono, F

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Journal Article

Importin 13: Eine Rundreise durch die Kernpore [Importin 13: a round trip through the nuclear pore]

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Bono, F
Research Group Structural Biology of mRNA Localization, Max Planck Institute for Developmental Biology, Max Planck Society;

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https://www.mpg.de/7742041/MPI_EB_JB_2014.pdf
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Citation

Bono, F. (2013). Importin 13: Eine Rundreise durch die Kernpore [Importin 13: a round trip through the nuclear pore]. Jahrbuch der Max-Planck-Gesellschaft, 2012/2013.

Cite as: https://hdl.handle.net/21.11116/0000-000F-CE35-E

Abstract

In eukaryotic cells DNA and transcription of RNAs are separated from protein biosynthesis occurring in the cytoplasm. Nucleus and cytoplasm are only connected via the nuclear pores. Transport betw een the compartments is aided by dedicated shuttling proteins, the karyopherins. Most karyopherins carry cargo only in one direction, either into (importins) or out of the nucleus (exportins), and then return empty handed. Importin 13 is an unusual karyopherin that can both import and export cargo. Our w ork revealed how Imp13 recognizes its cargoes and functions as a bidirectional transport factor.