Local current spread in electrically compact neurons of the fly

Borst, A; Single, S

doi:10.1016/s0304-3940(00)01043-0

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Local current spread in electrically compact neurons of the fly

MPS-Authors

/persons/resource/persons38770

Borst, A
Borst Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons276988

Single, S
Borst Group, Friedrich Miescher Laboratory, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Borst, A., & Single, S. (2000). Local current spread in electrically compact neurons of the fly. Neuroscience Letters, 285(2), 123-126. doi:10.1016/s0304-3940(00)01043-0.

Cite as: https://hdl.handle.net/21.11116/0000-000F-D7B6-1

Abstract

Analyses of active and passive membrane properties predict an asymmetry in the spread of electrical current through a neuron. Simulated current injection into a large-diameter compartment of a biophysically realistic model neuron causes a local potential shift that can spread throughout the cell. In contrast, causing the same local potential shift in the dendritic tip of the same neuron results in only minimal changes in electrical potential in the rest of the cell. Using calcium as a reporter of electrical activity in neurons in the fly's lobula plate we find that current injected into the thick axon caused depolarization throughout the cell, whereas activation of a dendritic region remained local. These results have important implications for the ability of integrating neurons to perform local computations of synaptic input without additional hardware. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.