Myelin lipid metabolism can provide energy for starved axons

Asadollahi, Ebrahim; Nave, Klaus-Armin

doi:10.1038/s41593-024-01750-z

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Myelin lipid metabolism can provide energy for starved axons

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Asadollahi, Ebrahim
Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Nave, Klaus-Armin
Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Citation

Asadollahi, E., & Nave, K.-A. (2024). Myelin lipid metabolism can provide energy for starved axons. Nature Neuroscience. doi:10.1038/s41593-024-01750-z.

Cite as: https://hdl.handle.net/21.11116/0000-000F-DDB7-A

Abstract

We reveal that lipid turnover in the myelin sheath generates a fatty acid pool in oligodendrocytes that can contribute to the energy balance of white matter tracts. We also demonstrate that when glucose levels are limiting, fatty acid metabolism can support glial cell survival and the basic functional integrity of myelinated axons.