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Journal Article

Long-term memory formation for voices during sleep in three-month-old infants

MPS-Authors

Näher,  Tim
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;

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Friedrich,  Manuela       
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, Humboldt University Berlin, Germany;

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Citation

Bastian, L., Kurz, E.-M., Näher, T., Zinke, K., Friedrich, M., & Born, J. (2024). Long-term memory formation for voices during sleep in three-month-old infants. Neurobiology of Learning and Memory, 215: 107987. doi:10.1016/j.nlm.2024.107987.


Cite as: https://hdl.handle.net/21.11116/0000-000F-E331-9
Abstract
The ability to form long-term memories begins in early infancy. However, little is known about the specific mechanisms that guide memory formation during this developmental stage. We demonstrate the emergence of a long-term memory for a novel voice in three-month-old infants using the EEG mismatch response (MMR) to the word “baby”. In an oddball-paradigm, a frequent standard, and two rare deviant voices (novel and mother) were presented before (baseline), and after (test) familiarizing the infants with the novel voice and a subsequent nap. Only the mother deviant but not the novel deviant elicited a late frontal MMR (∼850 ms) at baseline, possibly reflecting a long-term memory representation for the mother’s voice. Yet, MMRs to the novel and mother deviant significantly increased in similarity after voice familiarization and sleep. Moreover, both MMRs showed an additional early (∼250 ms) frontal negative component that is potentially related to deviance processing in short-term memory. Enhanced spindle activity during the nap predicted an increase in late MMR amplitude to the novel deviant and increased MMR similarity between novel and mother deviant. Our findings indicate that the late positive MMR in infants might reflect emergent long-term memory that benefits from sleep spindles.