English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

MPS-Authors
/persons/resource/persons262366

Froehlich,  Anna S.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262202

Gerstner,  Nathalie
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons222056

Ködel,  Maik
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262485

Yusupov,  Natan
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80291

Czamara,  Darina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons226837

Sauer,  Susann
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons128467

Roeh,  Simone
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons98244

Knauer-Arloth,  Janine
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80272

Binder,  Elisabeth B.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Froehlich, A. S., Gerstner, N., Gagliardi, M., Ködel, M., Yusupov, N., Matosin, N., et al. (2024). Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. NATURE NEUROSCIENCE, 27, 2021-2032. doi:10.1038/s41593-024-01742-z.


Cite as: https://hdl.handle.net/21.11116/0000-000F-EC08-F
Abstract
Aging is a complex biological process and represents the largest risk factor for neurodegenerative disorders. The risk for neurodegenerative disorders is also increased in individuals with psychiatric disorders. Here, we characterized age-related transcriptomic changes in the brain by profiling similar to 800,000 nuclei from the orbitofrontal cortex from 87 individuals with and without psychiatric diagnoses and replicated findings in an independent cohort with 32 individuals. Aging affects all cell types, with LAMP5(+)LHX6(+) interneurons, a cell-type abundant in primates, by far the most affected. Disrupted synaptic transmission emerged as a convergently affected pathway in aged tissue. Age-related transcriptomic changes overlapped with changes observed in Alzheimer's disease across multiple cell types. We find evidence for accelerated transcriptomic aging in individuals with psychiatric disorders and demonstrate a converging signature of aging and psychopathology across multiple cell types. Our findings shed light on cell-type-specific effects and biological pathways underlying age-related changes and their convergence with effects driven by psychiatric diagnosis.