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Journal Article

Extracellular vesicle-mediated trafficking of molecular cues during human brain development

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Forero,  Andrea
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

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Pipicelli,  Fabrizia
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Moser,  Sylvain
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;
RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Pütz,  Benno
RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Maccarrone,  Giuseppina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Di Giaimo,  Rossella
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

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Cappello,  Silvia
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Forero, A., Pipicelli, F., Moser, S., Baumann, N., Graetz, C., Pisfil, M. G., et al. (2024). Extracellular vesicle-mediated trafficking of molecular cues during human brain development. CELL REPORTS, 43(10): 114755. doi:10.1016/j.celrep.2024.114755.


Cite as: https://hdl.handle.net/21.11116/0000-000F-EBF4-5
Abstract
Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neurodegenerative disorders, but whether EVs display cell-type-specific features for cellular crosstalk during neurodevelopment is unknown. Here, using human-induced pluripotent stem cell-derived cerebral organoids, neural progenitors, neurons, and astrocytes, we identify heterogeneity in EV protein content and dynamics in a cell-type-specific and time-dependent manner. Our results support the trafficking of key molecules via EVs in neurodevelopment, such as the transcription factor YAP1, and their localization to differing cell compartments depending on the EV recipient cell type. This study sheds new light on the biology of EVs during human brain development.