Neutrophil trapping and nexocytosis, mast cell-mediated processes for 
inflammatory signal relay

Mihlan, Michael; Wissmann, Stefanie; Gavrilov, Alina; Kaltenbach, Lukas; Britz, Marie; Franke, Kristin; Hummel, Barbara; Imle, Andrea; Suzuki, Ryo; Stecher, Manuel; Glaser, Katharina M; Lorentz, Axel; Carmeliet, Peter; Yokomizo, Takehiko; Hilgendorf, Ingo; Sawarkar, Ritwick; Diz-Muñoz, Alba; Büscher, Jörg Martin; Mittler, Gerhard; Maurer, Marcus; Krause, Karoline; Babina, Magda; Erpenbeck, Luise; Frank, Marcus; Rambold, Angelika; Lämmermann, Tim

doi:10.1016/j.cell.2024.07.014

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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay

MPS-Authors

Mihlan, Michael
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Wissmann, Stefanie
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Gavrilov, Alina
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Kaltenbach, Lukas
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Hummel, Barbara
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Glaser, Katharina M
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Sawarkar, Ritwick
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons241896

Büscher, Jörg Martin
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons191219

Mittler, Gerhard
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons241710

Rambold, Angelika
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons204285

Lämmermann, Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S0092867424007748?via%3Dihub
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Citation

Mihlan, M., Wissmann, S., Gavrilov, A., Kaltenbach, L., Britz, M., Franke, K., et al. (2024). Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay. Cell, 187, 5316-5335. doi:10.1016/j.cell.2024.07.014.

Cite as: https://hdl.handle.net/21.11116/0000-000F-F7BC-7

Abstract

Neutrophils are sentinel immune cells with essential roles for antimicrobial defense. Most of our knowledge on neutrophil tissue navigation derived from wounding and infection models, whereas allergic conditions remained largely neglected. Here, we analyzed allergen-challenged mouse tissues and discovered that degranulating mast cells (MCs) trap living neutrophils inside them. MCs release the attractant leukotriene B4 to re-route neutrophils toward them, thus exploiting a chemotactic system that neutrophils normally use for intercellular communication. After MC intracellular trap (MIT) formation, neutrophils die, but their undigested material remains inside MC vacuoles over days. MCs benefit from MIT formation, increasing their functional and metabolic fitness. Additionally, they are more pro-inflammatory and can exocytose active neutrophilic compounds with a time delay (nexocytosis), eliciting a type 1 interferon response in surrounding macrophages. Together, our study highlights neutrophil trapping and nexocytosis as MC-mediated processes, which may relay neutrophilic features over the course of chronic allergic inflammation.