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A universal strategy to induce oxidative stress-mediated cell death in biological systems

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Möckl,  Leonhard
Möckl Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;

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Almahayni,  Karim
Möckl Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;

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Bachir Salvador,  Jana
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

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Spiekermann,  Malte
Möckl Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;

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Wehner,  Daniel
Wehner Research Group, Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Wehner Research Group, Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

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Citation

Möckl, L., Almahayni, K., Bachir Salvador, J., Conti, R., Widera, A., Spiekermann, M., et al. (2024). A universal strategy to induce oxidative stress-mediated cell death in biological systems. Research Square 10.21203/rs.3.rs-3753893/v1.


Cite as: https://hdl.handle.net/21.11116/0000-000F-FACB-3
Abstract
Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we integrate the spatio-temporal precision of light delivery and the structural versatility of bisacylphosphane oxides (BAPOs), establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.