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Journal Article

Shedding light on the unseen: how live imaging of translation could unlock new insights in developmental biology

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Bellec,  M
Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Citation

Dufourt, J., & Bellec, M. (2024). Shedding light on the unseen: how live imaging of translation could unlock new insights in developmental biology. COMPTES RENDUS BIOLOGIES, 347. doi:10.5802/crbiol.158.


Cite as: https://hdl.handle.net/21.11116/0000-0010-088B-9
Abstract
Recent advances in live imaging technologies have refined our
understanding of protein synthesis in living cells. Among the various
approaches to live imaging of translation, this perspective highlights
the use of antibody-based nascent peptide detection, a method that
enables visualization of single-molecule translation in vivo. . We
examine how these advances improve our understanding of biological
processes, particularly in developing organisms. In addition, we discuss
technological advances in this field and suggest further improvements.
Finally, we review some examples of how this method could lead to future
scientific breakthroughs in the study of translation and its regulation
in whole organisms.