Novel g-csf mimics and their applications

ElGamacy, M; Hernandez-Alvarez, B; Skokowa, J

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Novel g-csf mimics and their applications

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ElGamacy, M
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Hernandez-Alvarez, B
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Conservation of Protein Structure and Function Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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https://patents.google.com/patent/WO2021123033A1/en
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Citation

ElGamacy, M., Hernandez-Alvarez, B., & Skokowa, J.(2020). Novel g-csf mimics and their applications.

Cite as: https://hdl.handle.net/21.11116/0000-0010-0B0A-8

Abstract

The present invention relates to a protein having G-CSF-like activity comprising a) one or two polypeptide chains; b) a bundle of four α-helices; and c) two or three amino acid linkers that connect contiguous bundle-forming α-helices that are located on the same polypeptide chain, wherein each amino acid linker has a length between 2 and 20 amino acids. The invention also provides for a polynucleotide and a vector encoding the protein of the invention, host cells comprising said polynucleotide, a method for producing the protein of the invention and a pharmaceutical composition comprising the protein of the invention. The invention further relates to uses of the proteins of the invention as a research reagent and the use of the protein and/or pharmaceutical composition comprising the same as a medicament, e.g., for use in increasing stem cell production, for use in inducing hematopoesis and/or for use in mobilizing hematopoietic stem cells.