Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two 
Distinct Subtypes with Diverse Stemness Phenotypes

Yi, Guoqiang; Wierenga, Albertus T. J.; Petraglia, Francesca; Narang, Pankaj; Janssen-Megens, Eva M.; Mandoli, Amit; Merkel, Angelika; Berentsen, Kim; Kim, Bowon; Matarese, Filomena; Singh, Abhishek A.; Habibi, Ehsan; Prange, Koen H. M.; Mulder, Andre B.; Jansen, Joop H.; Clarke, Laura; Heath, Simon; van der Reijden, Bert A.; Flicek, Paul; Yaspo, Marie-Laure; Gut, Ivo; Bock, Christoph; Schuringa, Jan Jacob; Altucci, Lucia; Vellenga, Edo; Stunnenberg, Hendrik G.; Martens, Joost H. A.

doi:10.1016/j.celrep.2018.12.098

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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

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Yaspo, Marie-Laure
Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Yi, G., Wierenga, A. T. J., Petraglia, F., Narang, P., Janssen-Megens, E. M., Mandoli, A., et al. (2019). Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes. Cell Reports, 26(4), 1059-1069. doi:10.1016/j.celrep.2018.12.098.

Cite as: https://hdl.handle.net/21.11116/0000-0010-0B5D-B

Abstract

Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity and stemness. The second subtype is enriched for RUNX1 or spliceosome mutations, suggesting potential interplay between the 2 aberrations, and mainly depends on IRF family regulators. Cellular consequences in prognosis predict a relatively worse outcome for the first subtype. Our integrated profiling establishes a rich resource to probe AML subtypes on the basis of expression and chromatin data.