The Tricky Ways Bacteria Cope with Iron Limitation

Braun, V; Hantke, K

doi:10.1007/978-94-007-6088-2_2

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

書籍の一部

The Tricky Ways Bacteria Cope with Iron Limitation

MPS-Authors

/persons/resource/persons271640

Braun, V
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Braun, V., & Hantke, K. (2013). The Tricky Ways Bacteria Cope with Iron Limitation. In R., Chakraborty, V., Braun, K., Hantke, & P., Cornelis (Eds.), Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas (pp. 31-66). Dordrecht, The Netherlands: Springer.

引用: https://hdl.handle.net/21.11116/0000-0010-353E-E

要旨

Iron is an essential element for many key redox systems. It is difficult to acquire for cells under oxic conditions, since Fe3+ forms insoluble hydroxides. In the human host, iron is tightly bound to proteins. Bacteria invented iron transport systems which solubilize external Fe3+ by secreted low-molecular weight compounds, designated siderophores, or directly from the human proteins. Gram-negative bacteria contain an intricate energy-coupled iron transport mechanism across the outer membrane which lacks an energy source. The electrochemical potential of the cytoplasmic membrane delivers the energy. Transport across the cytoplasmic membrane is most frequently achieved by ABC transporters in Gram-positive and Gram-negative bacteria. Under anaerobic conditions, iron is the soluble Fe2+ form and transported different to Fe3+. Iron transport and intracellular iron concentrations are controlled by transcription regulation of iron transport genes. Transcription is turned on under iron-limiting growth conditions which usually exist in natural environments.