English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Poster

Computational Design of a Bivalent Cytokine Receptors Antagonist

MPS-Authors
/persons/resource/persons287253

Milijaš-Jotić,  M
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Milijaš-Jotić, M. (2024). Computational Design of a Bivalent Cytokine Receptors Antagonist. Poster presented at European RosettaCon 2024: Knowledge Transfer for Modern Protein Modeling and Design, Copenhagen, Denmark.


Cite as: https://hdl.handle.net/21.11116/0000-0010-3995-6
Abstract
Targeting multiple receptors with a single therapeutic agent can enhance treatment efficacy and overcome the limitations of monotherapy. We aimed to develop single-domain, bivalent blockers for IL-1RI and G-CSFR, two cytokine receptors implicated in several inflammatory and immune-related disorders. By combining receptor- binding fragments, we created single-domain proteins capable of forming stable receptor complexes. The designs were optimized using the Damietta protein design software for enhanced binding affinity and solubility, while molecular dynamics was employed to select the candidates for experimental testing. Preliminary results show that the constructs are soluble, thermostable, and bind both receptors with high affinity, offering a promising therapeutic strategy.