Simultaneous Measurement of CEST and $$$T_1$$$ using Model-based 
Multi-Pool-Lorentzian Look-Locker Reconstruction

Huemer, M; Scholand, N; Mackner, D; Stilianu, C; Zaiss, M; Stollberger, R

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Simultaneous Measurement of CEST and $$$T_1$$$ using Model-based Multi-Pool-Lorentzian Look-Locker Reconstruction

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Zaiss, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Huemer, M., Scholand, N., Mackner, D., Stilianu, C., Zaiss, M., & Stollberger, R. (2024). Simultaneous Measurement of CEST and $$$T_1$$$ using Model-based Multi-Pool-Lorentzian Look-Locker Reconstruction. In ISMRM & ISMRT Annual Meeting & Exhibition 2024.

Cite as: https://hdl.handle.net/21.11116/0000-0010-41B9-4

Abstract

Motivation: Conventional quantitative CEST experiments require the additional determination of $$$T_1$$$. CEST sequences include $$$T_1$$$ relaxation periods that can be exploited to estimate $$$T_1$$$ simultaneously to the CEST parameters.
Goal(s): The development of a technique for efficient simultaneous quantification of CEST contrast and $$$T_1$$$.
Approach: Integration of a FLASH acquisition train after conventional CEST saturations. Simultaneous CEST contrast and $$$T_1$$$ fitting is achieved by extending the Lorentzian model of the CEST spectrum with a Look-Locker model for the FLASH readout.
Results: The proof-of-concept was implemented, and first results are demonstrated in a two pools phantom and a four pool in vivo study.
Impact: The presented technique enables calculating $$$T_1$$$ corrected quantitative CEST results from one measurement. This simplifies the application of the apparent exchange-dependent relaxation ($$$MTR_{AREX}$$$), the quasi-steady-state$$$\;$$$contrast and other CEST metrics, which require a $$$T_1$$$ map, making them more accessible.