Homology-based structure, function, and domain prediction by HMM-HMM comparison

Söding, J

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Meeting Abstract

Homology-based structure, function, and domain prediction by HMM-HMM comparison

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Söding, J
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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https://predictioncenter.org/decoysets2019/pdfs/casp7_abstracts.pdf
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Citation

Söding, J. (2006). Homology-based structure, function, and domain prediction by HMM-HMM comparison. In Critical Assessment of Techniques for Protein Structure Prediction: Seventh Meeting: CASP7 (pp. 53).

Cite as: https://hdl.handle.net/21.11116/0000-0010-424B-0

Abstract

HHpred1 is an automatic version of our structure and function prediction server HHpred (http://hhpred.tuebingen.mpg.de/) and is the simplest of four related servers participating in CASP7 (HHpred1 to 3, BayesHH). It uses HMM-HMM comparison with integrated secondary structure comparison, correlation scoring, and a novel local HMM-HMM maximum a-posteriori probability (MAP) alignment scheme. Its main difference from a HHpred.2 in CASP6 is its use of a weekly updated HMM database derived from the PDB instead of SCOP and the use of a local MAP alignment scheme.