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Journal Article

Chromatin-Binding Proteins Moonlight as Mitotic Microtubule Regulators

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Yokoyama,  H       
Antonin Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Yokoyama, H. (2016). Chromatin-Binding Proteins Moonlight as Mitotic Microtubule Regulators. Trends in Cell Biology, 26(3), 161-164. doi:10.1016/j.tcb.2015.12.005.


Cite as: https://hdl.handle.net/21.11116/0000-0010-4692-A
Abstract
Some microtubule (MT)-associated proteins bind to MTs and chromatin simultaneously to fulfill their mitotic spindle function. By contrast, a growing number of chromatin-binding proteins leave mitotic chromatin and interact with MTs via their chromatin-binding domains. I discuss this switch from chromatin to MT binding as a key regulatory principle of spindle formation.