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Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology

MPS-Authors
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Lipp,  Ilona       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Kirilina,  Evgeniya       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Jäger,  Carsten       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Morawski,  Markus       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Jauch,  Anna
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine,  Kerrin       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Edwards,  Luke       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Helbling,  Saskia       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Rose,  Daniel       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Helms,  Gunther
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Eichner,  Cornelius       
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Anwander,  Alfred       
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Friederici,  Angela D.       
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf,  Nikolaus       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Lipp_pre.pdf
(Preprint), 3MB

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Lipp_pre_Suppl.pdf
(Supplementary material), 2MB

Citation

Lipp, I., Kirilina, E., Jäger, C., Morawski, M., Jauch, A., Pine, K., et al. (2024). Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology. bioRxiv. doi:10.1101/2024.12.06.627145.


Cite as: https://hdl.handle.net/21.11116/0000-0010-4CBF-3
Abstract
Chimpanzee brain maturation provides an invaluable framework for understanding the evolution of the human brain. We performed ultra-high resolution quantitative magnetic resonance imaging (qMRI) with histological validation on post mortem brains from captive and wild chimpanzees with a broad age range. We mapped developmental myelination and age-related iron accumulation across regions and layers of the neocortex. Compared to humans, chimpanzees showed more myelination and iron deposition in motor and premotor cortices, while the auditory cortex was more strongly myelinated in humans. Our model suggests that chimpanzees' cortical myelination was largely completed by the age of nine years, while iron accumulation continued throughout the lifespan. The regions with highest adult levels of myelin and iron took the longest to mature, challenging the widespread assumption that highly myelinated regions complete their development first. The reported maps and developmental curves provide a foundation for comparative neuroscience research and understanding of human brain evolution.